Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.
Identifieur interne : 001A45 ( Main/Exploration ); précédent : 001A44; suivant : 001A46Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.
Auteurs : R. Abes [France] ; A. A. Arzumanov [Russie] ; H. M. Moulton ; S. Abes [France] ; G. D. Ivanova ; P. L. Iversen ; M. J. Gait ; B. Lebleu [France]Source :
- Biochemical Society Transactions [ 0300-5127 ] ; 2007-08.
Abstract
Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most cationic CPPs bind to cell-associated glycosaminoglycans and are internalized by endocytosis, although the detailed mechanisms involved remain controversial. Sequestration and degradation in endocytic vesicles severely limits the efficiency of cytoplasmic and/or nuclear delivery of CPP-conjugated material. Re-routing the splicing machinery by using steric-block ON (oligonucleotide) analogues, such as PNAs (peptide nucleic acids) or PMOs (phosphorodiamidate morpholino oligomers), has consequently been inefficient when ONs are conjugated with standard CPPs such as Tat (transactivator of transcription), R(9) (nona-arginine), K(8) (octalysine) or penetratin in the absence of endosomolytic agents. New arginine-rich CPPs such as (R-Ahx-R)(4) (6-aminohexanoic acid-spaced oligo-arginine) or R(6) (hexa-arginine)-penetratin conjugated to PMO or PNA resulted in efficient splicing correction at non-cytotoxic doses in the absence of chloroquine. SAR (structure-activity relationship) analyses are underway to optimize these peptide delivery vectors and to understand their mechanisms of cellular internalization.
Url:
DOI: 10.1042/BST0350775
Affiliations:
- France, Russie
- Languedoc-Roussillon, Occitanie (région administrative)
- Montpellier
- PRES Sud de France, Université Montpellier 1
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000043
- to stream Hal, to step Curation: 000043
- to stream Hal, to step Checkpoint: 000219
- to stream Main, to step Merge: 001A55
- to stream Main, to step Curation: 001A45
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.</title>
<author><name sortKey="Abes, R" sort="Abes, R" uniqKey="Abes R" first="R." last="Abes">R. Abes</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-24481" status="OLD"> <orgName>Dynamique des interactions membranaires normales et pathologiques</orgName>
<orgName type="acronym">DIMNP</orgName>
<date type="end">2019-03-31</date>
<desc> <address> <addrLine>BT 24 CC 107 Place Eugène Bataillon 34095 MONTPELLIER CEDEX 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.dimnp.univ-montp2.fr</ref>
</desc>
<listRelation> <relation active="#struct-42570" type="direct"></relation>
<relation active="#struct-92690" type="direct"></relation>
<relation active="#struct-410122" type="direct"></relation>
<relation name="UMR5235" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName>
<orgName type="acronym">UM1</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-92690" type="direct"><org type="institution" xml:id="struct-92690" status="OLD"> <orgName>Université Montpellier 2 - Sciences et Techniques</orgName>
<orgName type="acronym">UM2</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>Place Eugène Bataillon - 34095 Montpellier cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp2.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno>
<orgName>Université de Montpellier</orgName>
<orgName type="acronym">UM</orgName>
<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.umontpellier.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5235" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
<orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName>
</affiliation>
</author>
<author><name sortKey="Arzumanov, A A" sort="Arzumanov, A A" uniqKey="Arzumanov A" first="A. A." last="Arzumanov">A. A. Arzumanov</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-97374" status="VALID"> <orgName>Engelhardt Institute of Molecular Biology</orgName>
<orgName type="acronym">ISTC</orgName>
<desc> <address> <addrLine>32, ul. Vavilova, 119991 Moscow</addrLine>
<country key="RU"></country>
</address>
<ref type="url">http://www.biochip.ru/</ref>
</desc>
<listRelation> <relation active="#struct-217892" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-217892" type="direct"><org type="institution" xml:id="struct-217892" status="VALID"> <orgName>Russian Academy of Sciences [Moscow]</orgName>
<orgName type="acronym">RAS</orgName>
<desc> <address> <addrLine>Leninsky Ave, 14, Moscow, Russie, 119991</addrLine>
<country key="RU"></country>
</address>
<ref type="url">http://www.ras.ru/en/index.aspx</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Moulton, H M" sort="Moulton, H M" uniqKey="Moulton H" first="H. M." last="Moulton">H. M. Moulton</name>
</author>
<author><name sortKey="Abes, S" sort="Abes, S" uniqKey="Abes S" first="S." last="Abes">S. Abes</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-24481" status="OLD"> <orgName>Dynamique des interactions membranaires normales et pathologiques</orgName>
<orgName type="acronym">DIMNP</orgName>
<date type="end">2019-03-31</date>
<desc> <address> <addrLine>BT 24 CC 107 Place Eugène Bataillon 34095 MONTPELLIER CEDEX 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.dimnp.univ-montp2.fr</ref>
</desc>
<listRelation> <relation active="#struct-42570" type="direct"></relation>
<relation active="#struct-92690" type="direct"></relation>
<relation active="#struct-410122" type="direct"></relation>
<relation name="UMR5235" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName>
<orgName type="acronym">UM1</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-92690" type="direct"><org type="institution" xml:id="struct-92690" status="OLD"> <orgName>Université Montpellier 2 - Sciences et Techniques</orgName>
<orgName type="acronym">UM2</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>Place Eugène Bataillon - 34095 Montpellier cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp2.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno>
<orgName>Université de Montpellier</orgName>
<orgName type="acronym">UM</orgName>
<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.umontpellier.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5235" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
<orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName>
</affiliation>
</author>
<author><name sortKey="Ivanova, G D" sort="Ivanova, G D" uniqKey="Ivanova G" first="G. D." last="Ivanova">G. D. Ivanova</name>
</author>
<author><name sortKey="Iversen, P L" sort="Iversen, P L" uniqKey="Iversen P" first="P. L." last="Iversen">P. L. Iversen</name>
</author>
<author><name sortKey="Gait, M J" sort="Gait, M J" uniqKey="Gait M" first="M. J." last="Gait">M. J. Gait</name>
</author>
<author><name sortKey="Lebleu, B" sort="Lebleu, B" uniqKey="Lebleu B" first="B." last="Lebleu">B. Lebleu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-24481" status="OLD"> <orgName>Dynamique des interactions membranaires normales et pathologiques</orgName>
<orgName type="acronym">DIMNP</orgName>
<date type="end">2019-03-31</date>
<desc> <address> <addrLine>BT 24 CC 107 Place Eugène Bataillon 34095 MONTPELLIER CEDEX 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.dimnp.univ-montp2.fr</ref>
</desc>
<listRelation> <relation active="#struct-42570" type="direct"></relation>
<relation active="#struct-92690" type="direct"></relation>
<relation active="#struct-410122" type="direct"></relation>
<relation name="UMR5235" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName>
<orgName type="acronym">UM1</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-92690" type="direct"><org type="institution" xml:id="struct-92690" status="OLD"> <orgName>Université Montpellier 2 - Sciences et Techniques</orgName>
<orgName type="acronym">UM2</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>Place Eugène Bataillon - 34095 Montpellier cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp2.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno>
<orgName>Université de Montpellier</orgName>
<orgName type="acronym">UM</orgName>
<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.umontpellier.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5235" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
<orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00167452</idno>
<idno type="halId">hal-00167452</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00167452</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00167452</idno>
<idno type="doi">10.1042/BST0350775</idno>
<date when="2007-08">2007-08</date>
<idno type="wicri:Area/Hal/Corpus">000043</idno>
<idno type="wicri:Area/Hal/Curation">000043</idno>
<idno type="wicri:Area/Hal/Checkpoint">000219</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000219</idno>
<idno type="wicri:doubleKey">0300-5127:2007:Abes R:cell:penetrating:peptide</idno>
<idno type="wicri:Area/Main/Merge">001A55</idno>
<idno type="wicri:Area/Main/Curation">001A45</idno>
<idno type="wicri:Area/Main/Exploration">001A45</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.</title>
<author><name sortKey="Abes, R" sort="Abes, R" uniqKey="Abes R" first="R." last="Abes">R. Abes</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-24481" status="OLD"> <orgName>Dynamique des interactions membranaires normales et pathologiques</orgName>
<orgName type="acronym">DIMNP</orgName>
<date type="end">2019-03-31</date>
<desc> <address> <addrLine>BT 24 CC 107 Place Eugène Bataillon 34095 MONTPELLIER CEDEX 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.dimnp.univ-montp2.fr</ref>
</desc>
<listRelation> <relation active="#struct-42570" type="direct"></relation>
<relation active="#struct-92690" type="direct"></relation>
<relation active="#struct-410122" type="direct"></relation>
<relation name="UMR5235" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName>
<orgName type="acronym">UM1</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-92690" type="direct"><org type="institution" xml:id="struct-92690" status="OLD"> <orgName>Université Montpellier 2 - Sciences et Techniques</orgName>
<orgName type="acronym">UM2</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>Place Eugène Bataillon - 34095 Montpellier cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp2.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno>
<orgName>Université de Montpellier</orgName>
<orgName type="acronym">UM</orgName>
<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.umontpellier.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5235" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
<orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName>
</affiliation>
</author>
<author><name sortKey="Arzumanov, A A" sort="Arzumanov, A A" uniqKey="Arzumanov A" first="A. A." last="Arzumanov">A. A. Arzumanov</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-97374" status="VALID"> <orgName>Engelhardt Institute of Molecular Biology</orgName>
<orgName type="acronym">ISTC</orgName>
<desc> <address> <addrLine>32, ul. Vavilova, 119991 Moscow</addrLine>
<country key="RU"></country>
</address>
<ref type="url">http://www.biochip.ru/</ref>
</desc>
<listRelation> <relation active="#struct-217892" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-217892" type="direct"><org type="institution" xml:id="struct-217892" status="VALID"> <orgName>Russian Academy of Sciences [Moscow]</orgName>
<orgName type="acronym">RAS</orgName>
<desc> <address> <addrLine>Leninsky Ave, 14, Moscow, Russie, 119991</addrLine>
<country key="RU"></country>
</address>
<ref type="url">http://www.ras.ru/en/index.aspx</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Moulton, H M" sort="Moulton, H M" uniqKey="Moulton H" first="H. M." last="Moulton">H. M. Moulton</name>
</author>
<author><name sortKey="Abes, S" sort="Abes, S" uniqKey="Abes S" first="S." last="Abes">S. Abes</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-24481" status="OLD"> <orgName>Dynamique des interactions membranaires normales et pathologiques</orgName>
<orgName type="acronym">DIMNP</orgName>
<date type="end">2019-03-31</date>
<desc> <address> <addrLine>BT 24 CC 107 Place Eugène Bataillon 34095 MONTPELLIER CEDEX 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.dimnp.univ-montp2.fr</ref>
</desc>
<listRelation> <relation active="#struct-42570" type="direct"></relation>
<relation active="#struct-92690" type="direct"></relation>
<relation active="#struct-410122" type="direct"></relation>
<relation name="UMR5235" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName>
<orgName type="acronym">UM1</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-92690" type="direct"><org type="institution" xml:id="struct-92690" status="OLD"> <orgName>Université Montpellier 2 - Sciences et Techniques</orgName>
<orgName type="acronym">UM2</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>Place Eugène Bataillon - 34095 Montpellier cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp2.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno>
<orgName>Université de Montpellier</orgName>
<orgName type="acronym">UM</orgName>
<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.umontpellier.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5235" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
<orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName>
</affiliation>
</author>
<author><name sortKey="Ivanova, G D" sort="Ivanova, G D" uniqKey="Ivanova G" first="G. D." last="Ivanova">G. D. Ivanova</name>
</author>
<author><name sortKey="Iversen, P L" sort="Iversen, P L" uniqKey="Iversen P" first="P. L." last="Iversen">P. L. Iversen</name>
</author>
<author><name sortKey="Gait, M J" sort="Gait, M J" uniqKey="Gait M" first="M. J." last="Gait">M. J. Gait</name>
</author>
<author><name sortKey="Lebleu, B" sort="Lebleu, B" uniqKey="Lebleu B" first="B." last="Lebleu">B. Lebleu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-24481" status="OLD"> <orgName>Dynamique des interactions membranaires normales et pathologiques</orgName>
<orgName type="acronym">DIMNP</orgName>
<date type="end">2019-03-31</date>
<desc> <address> <addrLine>BT 24 CC 107 Place Eugène Bataillon 34095 MONTPELLIER CEDEX 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.dimnp.univ-montp2.fr</ref>
</desc>
<listRelation> <relation active="#struct-42570" type="direct"></relation>
<relation active="#struct-92690" type="direct"></relation>
<relation active="#struct-410122" type="direct"></relation>
<relation name="UMR5235" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName>
<orgName type="acronym">UM1</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-92690" type="direct"><org type="institution" xml:id="struct-92690" status="OLD"> <orgName>Université Montpellier 2 - Sciences et Techniques</orgName>
<orgName type="acronym">UM2</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>Place Eugène Bataillon - 34095 Montpellier cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp2.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno>
<orgName>Université de Montpellier</orgName>
<orgName type="acronym">UM</orgName>
<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.umontpellier.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR5235" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
<orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1042/BST0350775</idno>
<series><title level="j">Biochemical Society Transactions</title>
<idno type="ISSN">0300-5127</idno>
<imprint><date type="datePub">2007-08</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most cationic CPPs bind to cell-associated glycosaminoglycans and are internalized by endocytosis, although the detailed mechanisms involved remain controversial. Sequestration and degradation in endocytic vesicles severely limits the efficiency of cytoplasmic and/or nuclear delivery of CPP-conjugated material. Re-routing the splicing machinery by using steric-block ON (oligonucleotide) analogues, such as PNAs (peptide nucleic acids) or PMOs (phosphorodiamidate morpholino oligomers), has consequently been inefficient when ONs are conjugated with standard CPPs such as Tat (transactivator of transcription), R(9) (nona-arginine), K(8) (octalysine) or penetratin in the absence of endosomolytic agents. New arginine-rich CPPs such as (R-Ahx-R)(4) (6-aminohexanoic acid-spaced oligo-arginine) or R(6) (hexa-arginine)-penetratin conjugated to PMO or PNA resulted in efficient splicing correction at non-cytotoxic doses in the absence of chloroquine. SAR (structure-activity relationship) analyses are underway to optimize these peptide delivery vectors and to understand their mechanisms of cellular internalization.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Russie</li>
</country>
<region><li>Languedoc-Roussillon</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Montpellier</li>
</settlement>
<orgName><li>PRES Sud de France</li>
<li>Université Montpellier 1</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Gait, M J" sort="Gait, M J" uniqKey="Gait M" first="M. J." last="Gait">M. J. Gait</name>
<name sortKey="Ivanova, G D" sort="Ivanova, G D" uniqKey="Ivanova G" first="G. D." last="Ivanova">G. D. Ivanova</name>
<name sortKey="Iversen, P L" sort="Iversen, P L" uniqKey="Iversen P" first="P. L." last="Iversen">P. L. Iversen</name>
<name sortKey="Moulton, H M" sort="Moulton, H M" uniqKey="Moulton H" first="H. M." last="Moulton">H. M. Moulton</name>
</noCountry>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Abes, R" sort="Abes, R" uniqKey="Abes R" first="R." last="Abes">R. Abes</name>
</region>
<name sortKey="Abes, S" sort="Abes, S" uniqKey="Abes S" first="S." last="Abes">S. Abes</name>
<name sortKey="Lebleu, B" sort="Lebleu, B" uniqKey="Lebleu B" first="B." last="Lebleu">B. Lebleu</name>
</country>
<country name="Russie"><noRegion><name sortKey="Arzumanov, A A" sort="Arzumanov, A A" uniqKey="Arzumanov A" first="A. A." last="Arzumanov">A. A. Arzumanov</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A45 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A45 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= Hal:hal-00167452 |texte= Cell-penetrating-peptide-based delivery of oligonucleotides: an overview. }}
This area was generated with Dilib version V0.6.33. |